GLP-1 weight loss drugs may affect relationships, single-source report finds
9 reported2 unconfirmed
A single-source report from The Guardian examines how GLP-1 weight-loss medications may affect romantic relationships, based on patient experiences and limited research. The article profiles Jennifer, a 57-year-old litigation attorney who lost 40kg using Mounjaro since 2023, and Joanna Wood, a 59-year-old former Australian diplomat who lost 25kg on a GLP-1. Both women reported changes in their relationships and self-perception after weight loss. The article notes that prescribing doctors often discuss physical side effects like nausea and vomiting, but effects on relationships are less understood. Early research suggests GLP-1s may impact dopamine reward pathways, potentially affecting sex drive, though evidence is mixed. A 2025 Kinsey study found 18% of respondents reported increased sexual desire on GLP-1s while 16% reported decreased desire. The article also cites a 2018 Swedish study of 1,958 bariatric surgery patients that found increased divorce or separation rates among couples after major weight loss.
What’s reported
Jennifer, 57, lost 40kg using Mounjaro starting in 2023; she had prior gastric sleeve surgery and regained weight.
Joanna Wood, 59, lost 25kg on a GLP-1 and started dating again after 14 years of singledom.
A 2025 Kinsey study showed 18% of respondents reported increased sexual desire on GLP-1s, 16% reported decreased desire.
A 2025 analysis of US FDA data identified 185 reports of sexual dysfunction, particularly among men taking GLP-1 receptor agonists.
A 2018 Swedish study of 1,958 bariatric surgery patients found increased incidence of divorce or separation for those in couples.
Australian GLP-1 prescriptions increased almost 10-fold since 2020; US use more than quadrupled.
Dr Terri-Lynne South, a GP specializing in obesity medicine, said GLP-1s may impact dopamine reward pathways, potentially reducing pleasure-seeking around alcohol, nicotine, and sex drives.
Dr Mark Mellor, a bariatric doctor, said rising self-confidence could lead people to question their relationships.
Psychologist Glenn Mackintosh said weight loss can reveal relationship problems, not cause them.
Open questions
Whether relationship changes are caused by the medication itself, weight loss, or other factors like age or perimenopause.
The long-term psychological effects of GLP-1 use on romantic relationships.
Key figures
Jennifer (surname withheld), 57, litigation attorney
Joanna Wood, 59, former Australian diplomat
Bruce Hart, 63, social worker
Dr Terri-Lynne South, GP specializing in obesity medicine
Dr Mark Mellor, bariatric doctor and specialist GP
Glenn Mackintosh, psychologist and clinical director of Weight Management Psychology Clinic, Brisbane
Dr Rebecca Puhl, psychologist at University of Connecticut
Sources: The Guardian
