Study links vitamin B12, folate deficiencies to chronic fatigue
The Story
Researchers at Osaka Metropolitan University in Japan found that low levels of vitamin B12 and folate may contribute to fatigue and lack of motivation in otherwise healthy adults. The study measured blood markers and assessed fatigue using standardized questionnaires in approximately 600 participants. Higher blood levels of homocysteine, which rise when these vitamins are low, were associated with greater physical fatigue in men and lower motivation in women.
Key Facts
- The study was led by Professor Hiroaki Kanouchi from Osaka Metropolitan University’s Graduate School of Human Life and Ecology.
- It included around 600 healthy Japanese adults.
- Researchers measured blood levels of homocysteine, folate, and vitamin B12.
- Fatigue and motivation were evaluated using the Chalder Fatigue Scale questionnaire and a Visual Analog Scale.
- Participants with higher homocysteine levels generally had lower folate and vitamin B12 levels, regardless of sex.
- Men with higher homocysteine were more likely to report greater physical fatigue.
- Women with elevated homocysteine were more likely to report lower motivation.
- Professor Kanouchi stated this may be the first report of its kind linking these vitamins to fatigue in healthy individuals.
- The findings were published in the journal Nutrients on May 28, 2026.
Conflicting Reports
No conflicting reports identified in the source article.
Still Unclear
The article reports a statistical association but does not establish a causal relationship. It is unclear whether these findings apply beyond the Japanese population studied.
Misconceptions
No widespread misconceptions addressed in the source article.
Key Figures
- Professor Hiroaki Kanouchi – lead researcher, Osaka Metropolitan University
Sources: ScienceDaily
